In a new publication in Scientific Reports entitled, Prostatic androgen receptor signaling shows an age-related and lobe-specific alteration in mice, Han Zhang, PhD candidate, and Ricke Lab colleagues describe age-related changes in prostatic androgen receptor signaling that may play a pivotal role in mediating prostate growth and function.
Their work shows that aging alters prostatic androgen receptor signaling in a lobe-specific manner in the mouse, which is associated with reduced proliferation. These findings provide insight into the expression pattern of androgen receptors in benign tissues, enhancing our understanding of the pathology of benign prostatic hyperplasia and associated lower urinary tract dysfunctions. To learn more about this exciting work, see the publication here.