University of Wisconsin–Madison

Ricke lab describes the role of nucleolar protein BOP1 in advanced prostate disease

New research from the Ricke lab and PhD candidate Jordan Vellky describes the implication of the nucleolar protein BOP1 in advanced prostate disease. Nucleolar protein BOP1 has been associated with multiple malignancies, but it has not been previously implicated in prostate cancer (CaP). Meta-analysis of publicly available data showed increased BOP1 expression in metastatic CaP, recurrent CaP, and was inversely associated with overall survival.  Multiplexed immunohistochemistry was used to analyze the expression and localization of BOP1 and nucleolar marker NOP56 in human tissue samples from various stages of CaP progression. Increased BOP1 expression was observed at later stages of CaP progression, coinciding with a localization change from nuclear to cytoplasmic. Functional significance of BOP1 in metastatic CaP was assessed by genetic knockdown. Collated, these data suggest a prognostic significance of BOP1 expression and localization in CaP progression and provide a foundation for further investigation into the functional role of nucleolar proteins in advanced CaP.